Publications

Link to complete list of William E. Balch publications here

Loguercio S., Calverley B.C., Wang C., Shak D., Zhao P., Sun S., Budinger G.R.S., Balch W.E. (2023) Understanding the host-pathogen evolutionary balance through Gaussian process modeling of SARS-CoV-2. Patterns (N Y). 4(8):100800 (Link).

Sun S., Wang C., Zhao P., Kline G.M., Grandjean J.M.D., Jiang X., Labaudiniere R., Wiseman R.L., Kelly J.W., Balch W.E. (2023) Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis. Cell Chem Biol. 20(1):22-42.  (Link).

Wang C., Angles F., Balch W.E. (2022) Triangulating variation in the population to define mechanisms for precision management of genetic disease. Structure. (Link).

Anglès F., Wang C., Balch W.E. (2022) Spatial Covariance analysis reveals the residue-by-residue thermodynamic contribution of variation to the CFTR fold. Commun. Biol. 5(1):356. (Link).

McQuattie-Pimentel, A. C., Ren, Z., Joshi, N., Watanabe, S., Stoeger, T., Chi, M., Lu, Z., Sichizya, L., Aillon, R. P., Chen, C. I., Soberanes, S., Chen, Z., Reyfman, P. A., Walter, J. M., Anekalla, K. R., Davis, J. M., Helmin, K. A., Runyan, C. E., Abdala-Valencia, H., Nam, K., Meliton, A. Y., Winter, D. R., Morimoto, R. I., Mutlu, G. M., Bharat, A., Perlman, H., Gottardi, C. J., Ridge, K. M., Chandel, N. S., Sznajder, J. I., Balch, W. E., Singer, B. D., Misharin, A. V., and Budinger, G. R. S. (2021)The Lung Microenvironment Shapes a Dysfunctional Response of Alveolar Macrophages in Aging. J Clin Invest. 131 (4). (Link)

Wang, C., Zhao, P., Sun, S., Teckman, J., and Balch, W. E. (2020) Leveraging Population Genomics for Individualized Correction of the Hallmarks of Alpha-1 Antitrypsin Deficiency. Chronic Obstr. Pulm. Dis. 7, 224-246. (Link).

Tran, D. T., Pottekat, A., Mir, S. A., Loguercio, S., Jang, I., Campos, A. R., Scully, K. M., Lahmy, R., Liu, M., Arvan, P., Balch, W. E., Kaufman, R. J., and Itkin-Ansari, P. (2020) Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role For Peroxiredoxin 4 in Proinsulin Folding. Diabetes. 2020 May 26;db200245. doi: 10.2337/db20-0245. Online ahead of print. (Link).

Singh, J., Hutt, D. M., Tait, B. D., Guy, N. C., Sivils, J. C., Ortiz, N. R., Payan, A. N., Komaragiri, S. K., Owens, J. J., Culbertson, D., Blair, L. J., Dickey, C., Kuo, S. Y., Finley, D., Dyson, H. J., Cox, M. B., Chaudhary, J., Gestwicki, J. E., and Balch, W. E. (2020) Management of Hsp90-Dependent Protein Folding by Small Molecule Targeting the Aha1 Co-Chaperone. Cell Chem. Biol. 27(3):292-305.e6, 412908. (Link).

Subramanian, K., Hutt, D.M., Scott, S.M., Gupta, V., Mao, S., Balch, W.E. (2020). Correction of Niemann-Pick type C1 trafficking and activity with histone deacetylase inhibitor valproic acid.  J. Biol. Chem. 2020, Apr 30. doi: 10.1074/jbc.RA119.010524. (Link).

Wang, C., Scott, S.M., Sun, S., Zhao. P., Hutt, D.M., Shao, H., Gestwicki, J.E., Balch, W.E. (2019). Individualized Management of Genetic Diversity in Niemann-Pick C1 through Modulation of the Hsp70 Chaperone System. Hum. Mol. Genet.1;29(1):1-19. doi: 10.1093/hmg/ddz215. PubMed PMID: 31509197. (Link).

Wang, C., Scott, S.M., Subramanian, K., Loguercio, S., Zhao, P., Hutt, D.M., Farhat, N.Y., Porter, F.D., Balch, W.E. (2019). Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process. Nat Commun. 10(1):5052. doi: 10.1038/s41467-019-12969-x. PMID: 31699992. (Link).

Angles, F., Hutt, D. M. & Balch, W. E. (2019). HDAC Inhibitors Rescue Multiple Disease-Causing CFTR Variants. Hum. Mol. Genet. 28, 1982-2000, doi:10.1093/hmg/ddz026. (Link).

Soberanes, S., Misharin, A.V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A.C., Cho, T., Hamanaka, R.B., Meliton, A.Y., Walter, J.M., Chen, C.I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F.J., Antalek, M., Adbala-Valencia, H., Chiarella, S.E., Sun, K.A., Woods, P.S., Ghio, A.J., Jain, M., Perlman, H., Ridge, K.M., Morimoto, R.I., Sznajder, J.I., Balch, W.E., Bhorade, S.M., Bharat, A., Prakriya, M., Chandel, N.S., Mutlu, G.M., Budinger, G.R.S. (2019). Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metab. 5;29(2):503. (Link).

Wang, C., Balch, W.E. (2018). Bridging Genomics to Phenomics at Atomic Resolution through Variation Spatial Profiling. Cell Rep. 24(8):2013-2028 e2016. DOI: 10.1016/j.celrep.2018.07.059. (Link).

Hutt, D.M., Loguercio, S., Roth, D.M., Su, A.I., Balch, W.E. (2018). Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3-mediated translation initiation. J. Biol. Chem. 293(35):13477-13495. doi: 10.1074/jbc.RA118.003192. (Link).

Hutt, D.M., Mishra, S.K., Roth, D.M., Larsen, M.B., Angles, F., Frizzell, R.A., Balch, W.E. (2018). Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy. J. Biol. Chem. 293(35):13682-13695. doi: 10.1074/jbc.RA118.002607. (Link).

Hutt, D.M., Loguercio, S., Campos, A.R., Balch, W.E. (2018). A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease. J. Mol. Biol. 2018 Jun 18. pii: S0022-2836(18)30613-2. doi: 10.1016/j.jmb.2018.06.017. (Link).

Subramanian, K., Rauniyar, N., Lavallee-Adam, M., Yates III, J.R., Balch, W.E. (2017). Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease. J. Mol. Proteomics. 16(11):1938-1957. doi: 10.1074/mcp.M116.064949. (Link).

Wang, C., Bouchecareilh, M., Balch, W.E. (2017). Measuring the Effect of Histone Deacetylase Inhibitors (HDACi) on the Secretion and Activity of Alpha-1 Antitrypsin. Methods Mol. Biol. 1639:185-193. (Link).

Misharin, A.V., Morales-Nebreda, L., Reyfman, P.A., Cuda, C.M., Walter, J.M., McQuattie-Pimente, A.C., Chen, C., Anekalla, K.R., Joshi, N., Williams, K.J.N., H., A.-V., Yacoub, T.J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F.J., Gates, K., Lam, A.P., Nicholson, T.T., Homan, P.J., Soberanes, S., Dominguez, S., Morgan, V.K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S.A., Bharat, A., Berdnikovs, S., Bhorade, S.M., Bartom, E.T., Morimoto, R.I., Balch, W.E., Sznajder, J.I., Chandel, N.S., Mutlu, G.M., Jain, M., Gottardi, C.J., Singer, B.D., Ridge, K.M., Bagheri, N., Shilatifard, A., Budinger, G.R., Perlman, H. (2017).  Monocyte-Derived Alveolar Macrophages Drive Lung Fibrosis And Persist In The Lung Over The Lifespan. J. Exp. Med. 214(8):2387-2404. doi: 10.1084/jem.20162152. (Link).

Budinger, G.S., Kohanski, R.A., Gan, W., Kobor, M.S., Amaral, L.A., Armanios, M., Kelsey, K.T., Pardo, A., Tuder, R., Macian, F., Chandel, N., Vaughan, D., Rojas, M., Mora, A.L., Kovacs, E., Duncan, S.R., Finkel, T., Choi, A., Eickelberg, O., Chen, D., Agusti, A., Selman, M., Balch, W.E., Busse, P., Lin, A., Morimoto, R., Sznajder, J.I., Thannickal, V.J. (2017).The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop. J. Gerontol. A. Biol. Sci. Med. Sci.  72(11):1492-1500. doi: 10.1093/gerona/glx090. (Link).

Pipalia, N.H., Subramanian, K., Mao, S., Ralph, H., Hutt, D.M., Scott, S.M., Balch, W.E., Maxfield, F.R. (2017). Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells. J. Lipid Res. 58(4):695-708. (Link).